A study was conducted in Greece to investigate the association between coffee drinking and diabetes development and potential mediation by oxidative stress and inflammatory biomarkers.
Researchers found that coffee drinkers were approximately half as likely to develop type 2 diabetes as those who didn't drink coffee. This may be due to an inflammation-lowering effect.
One of the authors, Demosthenes B. Panagiotakos reported that, "An inverse relation between coffee intake and diabetes has been reported in many prospective studies whereas some have
yielded insignificant results." (Reuters Health, 2015).
The studies conducted were observational so it is still unclear whether drinking coffee prevents type 2 diabetes. It is however a good deduction to initiate the basis of a cause-and-effect hypothesis.
The study began in 2001 and a random sample of 1514 adult men and women aged between 18 and 87 years were selected as subjects for this study. The researchers used a food frequency questionnaire to determine whether people drank coffee casually, habitually or abstained completely as well as reviewing other dietary and lifestyle dynamics. Oxidative stress and inflammatory markers were also evaluated.
From the group of participants there were 816 casual drinkers, 385 habitual drinkers and 239 non-coffee drinkers. The 10 year follow up occurred between 2011 and 2012 with 191 having developed type 2 diabetes. From the reports it was discovered that participants who had a higher intake of coffee were less likely to develop diabetes.
Habitual coffee drinkers (people who drank 1.5 or more cups a day) had a 54% lower chances of developing diabetes in comparison to non-coffee drinkers. These results were established even after accounting for smoking, high blood pressure, family history of diabetes and consumption of other caffeinated beverages.
Serum amyloid-A levels are inflammatory markers in the blood and when assessed in the study seemed to explain some of the relationship between coffee and diabetes. The higher intake of coffee, the lower the amyloid levels would be.
This study highlights the potential effect of long-term habitual coffee drinking against diabetes onset. The anti-inflammatory effect of several coffee components may be responsible for this protection.
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